Tuberculosis surveillance in Spain (2015-2021)

Authors

DOI:

https://doi.org/10.4321/s2173-92772023000300003

Keywords:

Tuberculosis; surveillance; Spain; RENAVE.

Abstract

Introduction: Tuberculosis (TB) is a notifiable disease in Spain. The objective of this study was to analyze its epidemiological situation during the period 2015-2021.

Method: Descriptive epidemiological analysis of TB cases reported by the CCAA to the National Epidemiological Surveillance (RENAVE) during 2015-2021. The analyzed variables included sex, age, CCAA, year of reporting, country of birth and residence, location, date of symptom onset and treatment initiation, treatment outcome, HIV status and diagnosis information. A descriptive analysis of the main variables and a temporo-spacial analysis of the notification rates were carried out.

Results: In 2021, 3,754 cases of TB were reported in Spain, with a notification rate of 7.61 per 100,000 population. This represented a 2.18% decrease compared to 2020 and a 28.07% decrease compared to 2015. Throughout the study period, a higher number of cases were observed in males (ratio 1.6-1.7), and there was a decreasing trend in notification rates in all CCAA, except Ceuta. This decline in rates was more pronounced for pulmonary forms. The case fatality remained stable during the study period. The quality of the provided information improved between 2015 and 2021 for some variables, but remained essential variables such as “treatment outcome” or HIV diagnosis.

Conclusions: The incidence of TB in Spain decreased from 2015 to 2021, particularly for pulmonary forms. Two of the WHO’s targets for 2020 were achieved, but the 2035 target appears unlikely. Significant deficiencies in the quality of information persist.

Downloads

Download data is not yet available.

References

Centro Nacional de Epidemiología. Instituto de Salud Carlos III. Red Nacional de Vigilancia Epidemiológica (RENAVE). Protocolos de la Red Nacional de Vigilancia Epidemiológica. [Internet]. 2013. [cited 2023 Jul 14] Available from: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Paginas/ProtocolosRENAVE.aspx

Red Nacional de Vigilancia Epidemiológica (RENAVE). Protocolo de Vigilancia de la Tuberculosis [Internet]. Instituto de Salud Carlos III; 2016. [cited 2023 Jul 14]. Available from: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Documents/PROTOCOLOS/Protocolo%20de%20Vigilancia%20de%20Tuberculosis.pdf

World Health Organization. The End TB strategy [Internet]. 2015 [cited 2023 Jul 14]. Available from: https://www.who.int/publications-detail-redirect/WHO-HTM-TB-2015.19

Ministerio de Sanidad, Consumo y Bienestar Social. Comisión de Salud Pública del Consejo Interterritorial del Sistema Nacional de Salud. Plan para la prevención y control de la tuberculosis en España. 2019 [cited 2023 Jul 14]. Available from: https://www.sanidad.gob.es/profesionales/saludPublica/prevPromocion/PlanTuberculosis/planTuberculosis.htm

Centro Nacional de Epidemiología. Instituto de Salud Carlos III. Red Nacional de Vigilancia Epidemiológica (RENAVE). Resultados de la vigilancia de la tuberculosis [Internet]. 2021. [cited 2023 Jul 14]. Available from: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Paginas/Resultados_Vigilancia_Tuberculosis.aspx

Centro Nacional de Epidemiología. Instituto de Salud Carlos III. Informe epidemiológico sobre la situación de la tuberculosis en España [Internet]. 2015. [cited 2023 Jul 14]. Available from: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Documents/archivos%20A-Z/Tuberculosis/RENAVE_vigilancia_TB_2015.pdf

Centro Nacional de Epidemiología. Instituto de Salud Carlos III. Informe epidemiológico sobre la situación de la tuberculosis en España [Internet]. 2021. [cited 2023 Jul 14]. Available from: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Documents/archivos%20A-Z/Tuberculosis/RENAVE_informe_Vigilancia%20TB_%202021.pdf

World Health Organization (WHO). Regional Committee for Europe, 65th session. (‎2015)‎. Sixty-fifth Regional Committee for Europe: Vilnius, 14–17: Tuberculosis action plan for the WHO European Region 2016–2020. [Internet]. Regional Office for Europe; 2015. [cited 2023 Jul 14] Available from: https://apps.who.int/iris/handle/10665/337750

Borgdorff MW, Nagelkerke NJ, Dye C, Nunn P. “Gender and tuberculosis: a comparison of prevalence surveys with notification data to explore sex differences in case detection”. Int Union Tuberc Lung Dis. 2000 Feb;4(2):123–32. PMID: 10694090

Connolly M, Nunn P. Women and tuberculosis. World Health Stat Q Rapp Trimest Stat Sanit Mond. 1996;49(2):115–9. PMID: 9050189.

Hertz D, Dibbern J, Eggers L, von Borstel L, Schneider BE. Increased male susceptibility to Mycobacterium tuberculosis infection is associated with smaller B cell follicles in the lungs. Sci Rep. 2020 Mar 20;10:5142. doi:10.1038/s41598-020-61503-3

Hayward SE, Rustage K, Nellums LB, van der Werf MJ, Noori T, Boccia D, Friedland JS, Hargreaves S. Extrapulmonary tuberculosis among migrants in Europe, 1995 to 2017. Clin Microbiol Infect. 2021 Sep;27(9):1347. doi: 10.1016/j.cmi.2020.12.006.

Glaziou P. Predicted impact of the COVID-19 pandemic on global tuberculosis deaths in 2020. medRxiv 20079582 [Preprint]; 2021 [cited 2023 Jul 14]. doi: 10.1101/2020.04.28.20079582. Available from: https://www.medrxiv.org/content/10.1101/2020.04.28.20079582v2

Xu C, Li T, Hu D, Zhang H, Zhao Y, Liu J. Predicted Impact of the COVID-19 Responses on Deaths of Tuberculosis – China, 2020. China CDC Wkly. 2021 Jan 8;3(2):21-4. doi: 10.46234/ccdcw2021.004

World Health Organization (WHO). Global tuberculosis report 2022 [Internet]. Geneva; 2022. [cited 2023 Jul 14]. Available from: https://www.who.int/publications/i/item/9789240061729

Ammon A, Kluge H. Ending tuberculosis in Europe - resetting the course in the post-COVID-19 era. Euro Surveill. 2023 Mar;28(12):2300164. doi: 10.2807/1560-7917.ES.2023.28.12.2300164

Guglielmetti L, Günther G, Leu C, Cirillo D, Duarte R, Garcia-Basteiro AL, Goletti D, Jankovic M, Kuksa L, Maurer FP, Méchaï F, Tiberi S, van Leth F, Veziris N, Lange C; Study Group on Mycobacteria of the European Society of Microbiology and Infectious Diseases (ESGMYC), European Society of Mycobacteriology (ESM), European Respiratory Society (ERS) and Tuberculosis Network European Trials group (TBnet). Rifapentine access in Europe: growing concerns over key tuberculosis treatment component. Eur Respir J. 2022 May 19;59(5):2200388. doi: 10.1183/13993003.00388-2022.

Drug-Resistant Tuberculosis in Europe. What Are We Waiting For? Ignacio Monedero-Recuero 1, https://doi.org/10.1164/rccm.201803-0497ED

Published

2023-09-29

How to Cite

1.
Gómez del Río S, Amillategui Dos Santos R, Herrera León L, Sastre M, Herrador Z. Tuberculosis surveillance in Spain (2015-2021). BES [Internet]. 2023 Sep. 29 [cited 2025 Apr. 3];31(3):176-89. Available from: //revista.isciii.es/index.php/bes/article/view/1316

Issue

Section

Estudios Epidemiológicos