Epidemiology of acute respiratory infections in Spain during the 2024-2025 season

Authors

DOI:

https://doi.org/10.4321/s2173-92772026000200006

Keywords:

acute respiratory infection; severe acute respiratory infection; influenza; COVID-19; RSV; surveillance

Abstract

Introduction: The Acute Respiratory Infection Surveillance System (SiVIRA) provides integrated monitoring of acute respiratory infections, particularly those caused by influenza, SARS-CoV-2 and respiratory syncytial virus (RSV). This work presents the results for the 2024-25 season.

Method: All cases that attended primary care for acute respiratory infection (ARI) or were admitted for severe ARI (SARI) were collected, and weekly incidence rates were calculated, weighted by age, sex and autonomous community. A representative sample was selected for microbiological study, and the percentage of positivity to influenza, SARS-CoV-2 and RSV was calculated.

Results: ARI and SARI rates peaked between weeks 02/2025 and 04/2025, with 803 cases/100,000 inhabitants and 24.2 hospitalizations/100,000 inhabitants, respectively. The influenza epidemic developed between weeks 50/2024 and 09/2025, peaking in week 04/2025. Type A predominated (57% of ARI cases and 90% of hospitalizations). COVID-19 changed its temporal pattern, with no epidemic wave in autumn-winter but a preserved spring-summer wave, peaking in week 38/2025. The BA.2.86 variant initially predominated, followed by XFG, which began to circulate from week 16/2025. RSV circulation started in week 46/2024 with ARI cases peaking in week 51/2024 and hospitalizations in week 01/2025.

Discussion: In the 2024-25 season, the circulation of influenza, SARS-CoV-2 and RSV was more staggered, with no winter wave of COVID-19. This resulted in lower weekly rates of acute respiratory infection and hospitalization than in previous seasons.

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References

Red Nacional de Vigilancia Epidemiológica (RENAVE), Centro Nacional de Epidemiología, Centro Nacional de Microbiología, Instituto de Salud Carlos III. Protocolo para la vigilancia centinela de infección respiratoria aguda (IRAs) en Atención Primaria en España. Temporada 2024-2025 [Internet]. 2024. Disponible en: https://cne.isciii.es/es/servicios/enfermedades-transmisibles/enfermedades-a-z/gripe-covid-19-y-otros-virus-respiratorios

Red Nacional de Vigilancia Epidemiológica (RENAVE), Centro Nacional de Epidemiología, Centro Nacional de Microbiología, Instituto de Salud Carlos III. Protocolo para la vigilancia centinela de infección respiratoria aguda grave (IRAG) en hospitales en España. Temporada 2024-2025 [Internet]. 2024. Disponible en: https://cne.isciii.es/es/servicios/enfermedades-transmisibles/enfermedades-a-z/gripe-covid-19-y-otros-virus-respiratorios

Instituto de Salud Carlos III. Metodología para la vigilancia de las infecciones respiratorias agudas en España. SiVIRA, temporada 2024-2025 [Internet]. 2024. Disponible en: https://cne.isciii.es/documents/d/cne/metodologia-sivira-sistemas-y-fuentes-de-informacion-temporada-2024-25-1

Ministerio de Sanidad. Grupo de trabajo de inmunización frente a VRS de la Ponencia de Programa y Registro de Vacunaciones. Recomendaciones de inmunización pasiva para prevención de enfermedad grave por VRS en la población infantil. Comisión de Salud Pública del Consejo Interterritorial del Sistema Nacional de Salud [Internet]. 2024. Disponible en: https://www.sanidad.gob.es/areas/promocionPrevencion/vacunaciones/comoTrabajamos/docs/VRS_infantil.pdf

Ministerio de Sanidad. Inmunización pasiva con nirsevimab (Beyfortus®) frente a virus respiratorio sincitial para la temporada 2024-2025 [Internet]. 2024. Disponible en: https://www.sanidad.gob.es/areas/promocionPrevencion/vacunaciones/comoTrabajamos/docs/Preguntasyrespuestas_Inmunizacion_frente_VRS_Ciudadanos.pdf

Aguilar Figueroa D, Pérez-Gimeno G, Núñez O, Monge S; SiVIRA Surveillance and Vaccine Effectiveness Working Group. Burden of severe disease associated with influenza, SARS-CoV-2 and RSV in Spain during the 2024-2025 winter season. Influenza Other Respir Viruses. 2025;19(11):e70190. doi:10.1111/irv.70190

Vega-Piris L, Carretero SG, Mayordomo JL, Zarzuelo MBR, Álvarez Río V, García VG, et al.; SARI Sentinel Surveillance Group. Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years. J Infect. 2024;89(5):106292. doi:10.1016/j.jinf.2024.106292

Pérez-Gimeno G, Mazagatos C, Lorusso N, Basile L, Martínez-Pino I, Corpas Burgos F, et al. Effectiveness of influenza vaccines in children aged 6 to 59 months: a test-negative case-control study at primary care and hospital level, Spain 2023/24. Eurosurveillance [Internet]. 2024;29(40). Disponible en: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.40.2400618

Campos Mena S, Pérez-Gimeno G, Lorusso N, Álvarez Río V, Basile L, Batalla Rebollo N, et al.; SiVIRA group. Monitoring effectiveness of nirsevimab immunization against RSV hospitalization using surveillance data: a test-negative case-control study, Spain, October 2024-March 2025. Epidemiol Infect. 2025;154:e5. doi:10.1017/S0950268825100782

Rojas-Benedicto A, Pérez-Gimeno G, Mendioroz J, Pedrosa Corral I, López Torrijos M, Rumayor M, et al. Effectiveness of the autumnal COVID-19 vaccine dose during the winter and summer waves of the 2023/24 season in Spain. Expert Rev Vaccines. 2025;24(1):980-990. doi:10.1080/14760584.2025.2576243

Rojas-Castro M, Verdasca N, Monge S, De Mot L, Trobajo-Sanmartín C, Duffy R, et al. COVID-19 vaccine effectiveness against hospitalization in older adults, VEBIS hospital network, Europe, September 2024-May 2025. Influenza Other Respir Viruses. 2025;19(11):e70191. doi:10.1111/irv.70191

Savulescu C, Ganser I, Nicolay N, Lajot A, Campos S, Martínez-Baz I, et al.; VEBIS hospital network RSV IE group. Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged <24 months hospitalised for severe acute respiratory infection, European pilot study, 2024-2025. Euro Surveill. 2025;30(45):2500816. doi:10.2807/1560-7917.ES.2025.30.45.2500816

Laniece Delaunay C, Verdasca N, Monge S, Domegan L, Sève N, Buda S, et al.; European primary care VE group. COVID-19 vaccine effectiveness against medically attended symptomatic SARS-CoV-2 infection among target groups in Europe, October 2024-January 2025, VEBIS primary care network. Influenza Other Respir Viruses. 2025;19(5):e70120. doi:10.1111/irv.70120

World Health Organization. Global respiratory virus activity weekly update [Internet]. Geneva: WHO. Disponible en: https://www.who.int/teams/global-influenza-programme/surveillance-and-monitoring/influenza-updates/current-influenza-update

Instituto de Salud Carlos III. Informe semanal de vigilancia de IRAs e IRAG. Semana 39/2025. España [Internet]. 2025. Disponible en: https://docsivira.isciii.es/informe_semanal_SiVIRA_202539.html

Instituto de Salud Carlos III. Informe anual de vigilancia de IRAs e IRAG (semana 40/2023 a semana 39/2024). España [Internet]. 2024. Disponible en: https://cne.isciii.es/documents/d/cne/informe_anual_sivira_2023-24_20250211

Instituto de Salud Carlos III. Informe anual de vigilancia de IRAs e IRAG (semana 40/2024 a semana 39/2025). España [Internet]. 2025. Disponible en: https://cne.isciii.es/documents/d/cne/informe_anual_sivira_2024_2025_20260312_publicar

Instituto Nacional de Estadística (INE). Estadística continua de población [Internet]. Madrid: INE; 2024. Disponible en: https://www.ine.es/dyngs/INEbase/es/operacion.htm?c=Estadistica_C&cid=1254736177095&menu=ultiDatos&idp=1254735572981

European Medicines Agency. Beyfortus (nirsevimab) [Internet]. Disponible en: https://www.ema.europa.eu/en/medicines/human/EPAR/beyfortus

Núñez O, Olmedo C, Moreno-Perez D, Lorusso N, Fernández Martínez S, Pastor Villalba PE, et al. Effectiveness of catch-up and at-birth nirsevimab immunisation against RSV hospital admission in the first year of life: a population-based case–control study, Spain, 2023/24 season. Eurosurveillance [Internet]. 2025;30(5). Disponible en: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.5.2400596.

Pastor-Barriuso R, Núñez O, Monge S; the Nirsevimab Effectiveness Study Collaborators. Infants needed to immunise with nirsevimab to prevent one RSV hospitalisation, Spain, 2023/24 season. Eurosurveillance [Internet]. 2025;30(6). Disponible en: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.6.2500040.

Mazagatos C, Mendioroz J, Rumayor MB, Gallardo García V, Álvarez Río V, Cebollada Gracia AD, et al. Estimated impact of nirsevimab on the incidence of respiratory syncytial virus infections requiring hospital admission in children <1 year, weeks 40, 2023 to 8, 2024, Spain. Influenza Other Respir Viruses [Internet]. 2024;18(5):e13294. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/irv.13294.

Campos Mena S, Pérez-Gimeno G, Lorusso N, Álvarez Río V, Basile L, Batalla Rebollo N, García-Comas L, Andreu Ivorra B, Pérez-Panadés J, Ramos Marín V, Castrillejo D, Fernández Ibáñez A, Rafael de la Cruz López MÁ, Núñez O, Monge S; SiVIRA group. Monitoring effectiveness of nirsevimab immunization against RSV hospitalization using surveillance data: a test-negative case-control study, Spain, October 2024-March 2025. Epidemiol Infect. 2025 Dec 9;154:e5.

European Centre for Disease Prevention and Control (ECDC), WHO Regional Office for Europe. European Respiratory Virus Surveillance Summary (ERVISS) [Internet]. Stockholm: ECDC; 2026 [cited 2026 May 28]. Available from: https://erviss.org/

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Published

2026-07-01

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Section

Estudios Epidemiológicos

How to Cite

1.
Epidemiology of acute respiratory infections in Spain during the 2024-2025 season. BES [Internet]. 2026 Jul. 1 [cited 2026 Sep. 16];34(2):100-24. Available from: https://revista.isciii.es/index.php/bes/article/view/1531